The Long Darkness Before Dawn

Each week, good news about vaccines or antibody treatments surfaces, offering hope that an end to the pandemic is at hand.

And yet this holiday season presents a grim reckoning. The United States has reached an appalling milestone: more than one million new coronavirus cases every week. Hospitals in some states are full to bursting. The number of deaths is rising and seems on track to easily surpass the 2,200-a-day average in the spring, when the pandemic was concentrated in the New York metropolitan area.

Our failure to protect ourselves has caught up to us.

The nation now must endure a critical period of transition, one that threatens to last far too long, as we set aside justifiable optimism about next spring and confront the dark winter ahead. Some epidemiologists predict that the death toll by March could be close to twice the 250,000 figure that the nation surpassed only last week.

“The next three months are going to be just horrible,” said Dr. Ashish Jha, dean of Brown University’s School of Public Health and one of two dozen experts interviewed by The New York Times about the near future.

This juncture, perhaps more than any to date, exposes the deep political divisions that have allowed the pandemic to take root and bloom, and that will determine the depth of the winter ahead. Even as the Centers for Disease Control and Prevention urged Americans to avoid holiday travel and many health officials asked families to cancel big gatherings, more than six million Americans took flights during Thanksgiving week, which is about 40 percent of last year’s air traffic. And President Trump, the one person most capable of altering the trajectory between now and spring, seems unwilling to help his successor do what must be done to save the lives of tens of thousands of Americans.

President-elect Joseph R. Biden Jr. has assembled excellent advisers and a sensible plan for tackling the pandemic, public health experts said. But Mitchell Warren, the founder of AVAC, an AIDS advocacy group that focuses on several diseases, said Mr. Biden’s hands appeared tied until Inauguration Day on Jan. 20: “There’s not a ton of power in being president-elect.”

A fatal inaction

By late December, the first doses of vaccine may be available to Americans, federal officials have said. Priorities are still being set, but vaccinations are expected to go first to health care workers, nursing home residents and others at highest risk. How long it will take to reach younger Americans depends on many factors, including how many vaccines are approved and how fast they can be made.

In mid-October, I surprised some New York Times readers by shifting from pessimism to optimism, with the epidemic in the United States most likely ending sooner than I expected. Now that at least two vaccines with efficacy greater than 90 percent have emerged, I am even more hopeful about what 2021 holds.

But even as the medical response to the virus is improving, the politics of public health remain a deeply vexing challenge.

The regions of the country now among those hit hardest by the virus — Midwestern and Mountain States and rural counties, including in the Dakotas, Iowa, Nebraska and Wyoming — are the ones that voted heavily for Mr. Trump in the recent election. The president could help save his millions of supporters by urging them to wear masks, avoid crowds and skip holiday gatherings this year. But that seemed unlikely to occur, many health experts said.

“That is outside of his DNA,” said Dr. William Schaffner, a preventive medicine specialist at Vanderbilt University medical school. “It would mean admitting he was wrong and Tony Fauci was right.”

In a bitter paradox, some experts noted, Mr. Trump could have been the hero of this pandemic. Operation Warp Speed, which his administration announced in May, appears on track to deliver vaccines and therapies in record-breaking time. The United States may well become the first country to bring the virus to heel through pharmaceutical prowess.

Had Mr. Trump heeded his medical advisers in late spring and adopted measures to curb new infections, the nation could now be on track to exit the epidemic next year with far fewer deaths per capita than many other nations.

But during his campaign, Mr. Trump rarely mentioned Operation Warp Speed; it has invested more than $12 billion in six vaccines based on three complex new technologies, as well as antibody therapies with nearly unpronounceable names like bamlanivimab.

Some health experts expressed concern that Mr. Trump might continue to undermine the coronavirus effort after he leaves office, by contradicting and diminishing any measure proposed by Mr. Biden.

“The thinking over here,” said Dr. David L. Heyman, a former C.D.C. official who now oversees the Center on Global Health Security at Chatham House in London, “is that he will continue to harass the White House to mobilize his people for 2024 for himself or his daughter or sons.”

The fight over masks

The antidote to hopelessness is agency, and Americans can protect themselves even without Mr. Trump’s advice by wearing masks and keeping their distance from others.

Reluctant officials are finally coming around to ordering such measures. The governors of Iowa and New Hampshire issued mask mandates for the first time in mid-November; the governors of Kansas, North Carolina and Hawaii strengthened theirs. But average Americans are sharply divided over masks.

“There is pretty broad support for mask mandates even among Republicans,” said Martha Louise Lincoln, a medical historian at San Francisco State University. “But among extreme right-wing voters there’s still a perception that they’re a sign of weakness or a symbol of being duped.”

The Centers for Disease Control and Prevention issued new guidelines on Nov. 10, advocating more clearly than before that everyone, infected or healthy, should wear a mask.

Various studies, involving machines puffing fine mists, have shown that high-quality masks can significantly reduce the spread of pathogens between people in conversation.

And the common-sense evidence that masks work has become overwhelming. Dozens of “superspreader events” have taken place in venues where most people were not masked — in bars and restaurants, at summer camps, at funerals, on airplanes, in churches, at choir practice.

In contrast, none have been known to occur in venues where most people wore masks, such as grocery stores. One well-known C.D.C. study showed that, even in a Springfield, Mo., hair salon where two stylists were infected, not one of the 139 customers whose hair they cut over the course of 10 days caught the disease. A city health order had required that both the stylists and the customers be masked.

Even in the most dangerous environments — hospital emergency rooms — there have been no reported superspreader events since personal protective gear became widely available. (Many individual doctors and nurses have been infected, however; an incident in South Bend, Ind., in which multiple nurses were infected turned out to be related to a wedding.)

By contrast, the White House, where masks have been shunned, has been the scene of at least one, and possibly more superspreader events.

A study by the Institute for Health Metrics and Evaluation at the University of Washington estimated that 130,000 lives could be saved by February if mask use became universal in the United States immediately. Masks can also preserve the economy: A study by Goldman Sachs estimated that universal use would save $1 trillion that may be lost to business shutdowns and medical bills.

Mr. Biden has said that he intends to tackle the pandemic from his first full day in office, on Jan. 21. But because coronavirus deaths follow new cases by some weeks, any results of his actions may not be apparent before early spring.

The experts generally praised the panel of advisers chosen by Mr. Biden, depicting them as reputable scientists who could credibly reach out to many groups hard-hit by the pandemic, including Black and Hispanic Americans.

But several experts, some of whom spoke anonymously to avoid offending friends and colleagues, said the panel needed different skills and a different kind of balance.

Some felt that it should have more scientific expertise, and suggested recruiting more vaccinologists, such as Dr. Paul A. Offit of Children’s Hospital of Philadelphia, and more epidemiologists, such as Harvard’s Marc Lipsitch and Natalie E. Dean of the University of Florida.

Others said the panel needed more behavioral scientists adept at fighting rumors, which have been a major obstacle.

“We’re facing extremely complex and poorly understood dynamics around disinformation, conspiratorial theories, paranoia and mistrust,” Dr. Lincoln noted.

Among the suggested names with those skills were Heidi J. Larson of the Vaccine Confidence Project in London, Carl T. Bergstrom of the University of Washington and Zeynep Tufekci of the University of North Carolina.

Others said the panel had too many members tied to the Obama-Biden administration. Dr. Ezekiel J. Emanuel, for example, was an architect of the Affordable Care Act and Dr. Eric Goosby was Mr. Obama’s global AIDS coordinator. To reach Mr. Trump’s base, they said, the panel needs credible Republican experts.

“Otherwise,” said Dr. Leana Wen, a former Baltimore health commissioner, “there will be even more of a mistaken perception that this is Democrats and doctors trying to shut down the economy, when actually controlling the virus is key to economic recovery.”

Experts suggested adding Dr. Bill Frist, a transplant surgeon and former Republican senator, or Dr. Marc K. Siegel, an internist and Fox News opinion writer.

Mr. Warren suggested consulting marketing experts and recruiting “everyone from Santa Claus to LeBron James” as trusted spokesmen.

Another expert suggested adding Dr. Mehmet C. Oz, a heart surgeon and television personality who was criticized for promoting hydroxychloroquine on Fox News (he later relented), and possibly even asking Sean Hannity and Tucker Carlson to join, because they are popular with Mr. Trump’s base and might be persuaded to accept science that would save the lives of their own viewers.

Mr. Biden’s plan for tackling the pandemic is outlined on his website.

It calls for far more widespread testing, delivered free; a ban on out-of-pocket costs for medical care for the virus; having the military build temporary hospitals if necessary; cooperation with American businesses to create more personal protective gear and ventilators; more food relief for the poor, and other measures.

Mr. Biden has said he supports a national mask mandate, although his plan calls on governors to impose state ones.

All the experts interviewed by The Times praised the plan, but several felt it was not aggressive enough. The pandemic is raging so far beyond control, they argued, that it can be contained only with deeply unpopular but necessary measures, such as rigorously enforced mask laws, closing bars and restaurants, requiring regular testing in schools and workplaces, isolating the infected away from their families, prohibiting travel from high-prevalence areas to low ones, and imposing quarantines that are enforced rather than merely requested.

Many other countries have imposed such measures despite fierce opposition from some citizens, they said, and they have helped.

“Colleges are the Wuhans of this fall surge,” said Dr. Howard Markel, a medical historian at the University of Michigan’s medical school. Universities, he and other experts said, must stop students from going back and forth between their hometowns and college towns, both of which have many vulnerable residents.

The key to enforcing mask laws, noted Dr. Robert Klitzman, a psychiatrist and bioethicist at Columbia University’s Mailman School of Public Health, is to punish not people but the owners of buildings that ignore restrictions; Quebec, he noted, fines stores $4,500 if customers are unmasked.

But after a very divisive election, other experts said, it will be hard to get many Americans to cooperate, especially if Mr. Trump encourages resistance.

Also, there are legal limits on what the federal government can do. American “sanitary codes” and quarantine laws are overwhelmingly based on state and local powers, many of which were granted in the 19th century, when epidemics constantly swept the nation’s cities. The federal government’s powers generally extend to interstate matters.

So, for instance, while the Biden administration could easily make it a federal crime to refuse to wear a mask on a cross-country flight — or put offenders on the “no fly list” that was created after the Sept. 11, 2001, attack on the World Trade Center — it probably cannot make every resident of South Dakota wear a mask if Gov. Kristi Noem and the State Legislature oppose the measure. Ms. Noem has said that she will not enforce mask mandates or lockdowns even if Mr. Biden, as president, orders them.

The hope for vaccines

The health experts interviewed by The Times all expressed excitement that the Pfizer/BioNTech and Moderna vaccines were reported to be 95 percent effective with no serious safety problems. On Nov. 23, a third vaccine, from AstraZeneca, also appeared to be effective, although exactly how effective is disputed.

“This is an amazing feat of science we’ve just seen, to go from a gene sequence on Jan. 10 to a vaccine by Nov. 10,” said Dr. Lawrence Corey, who is harmonizing disparate vaccine trials so their results can be easily compared.

However, experts still want to read the data, not just what Dr. Offit called “science by news release.”

(Pharmaceutical companies often wait until they have publishable data before announcing clinical trial results. But when news is likely to jolt a stock’s price, it is released immediately to reduce the chance of anyone connected to the company engaging in insider trading, or even appearing to.)

Mr. Biden will inherit the fruits of Operation Warp Speed and oversee their distribution. Members of his transition team, speaking anonymously because they were not authorized to reveal its deliberations, said they were already discussing two sensitive topics: whether to create a secure way for vaccinated individuals to prove they have received both shots, and whether Covid vaccines should ultimately be made mandatory — either by the federal government, or by state governments, employers, school systems or the like.

Dr. W. Ian Lipkin, director of the Center for Infection and Immunity at Columbia University’s Mailman School of Public Health, noted that his institution already has mandatory testing for all students and staff. He said that companies he advises would like to eventually make vaccination mandatory for all employees, but would prefer the government took the lead by requiring them.

At Dr. Offit’s pediatric hospital, every member must have had all routine vaccines and get an annual flu shot — or face dismissal.

“It’s not optional,” he said. “You’re taking care of children. And yes, down the line, I think vaccination will have to be mandatory. It’s your responsibility as a citizen.”

The next dozen weeks will be long and painful. But spring is likely to bring highly effective vaccines and a renewed commitment to medical leadership, something that has been missing under Mr. Trump.

“The C.D.C. will have to be rebuilt, and its guidelines and the F.D.A.’s have to be promptly re-evaluated,” said Dr. Robert L. Murphy, director of the Institute for Global Health at Northwestern University’s medical school. “The Biden team will move quickly. It’s not like they don’t know what to do.”

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