Study says all gargle samples were positive and comparable to swab samples. (Representational)
New Delhi:
A study published by the Indian Council of Medical Research (ICMR) has said that gargle lavage may be a feasible alternative to swabs for sample collection for the detection of SARS-CoV-2.
The primary objective of this study was to assess agreement between gargle lavage and swab as an appropriate respiratory sample for the detection of SARS-CoV-2, said ICMR. The secondary objective was to assess the patient acceptability of the two sampling methods.
The top researchers at ICMR conducted a cross-sectional study at AIIMS hospital in Delhi from May-June on 50 COVID-19 patients.
The ICMR study pointed out that whether the risk of aerosol generation was similar to swab collection (commonly leads to coughing and sneezing) or higher was not clear.
“To minimize the risk of transmission due to aerosols and to maximize the benefits of this method of collection, it would be best to employ it for home collection. Furthermore, it cannot be used in patients who are critically ill as well as in young children/patients who may not be able to follow instructions/perform gargle,” it said.
“Preliminary results of the study show that the gargle lavage may be a viable alternative to swabs for sample collection for the detection of SARS-CoV-2. Adoption of gargle lavage for sample collection will have a significant impact as it will enable easy self-collection, relieve healthcare workers and also lead to substantial cost savings by reducing the need for swabs and personal protective equipment,” concluded the findings of the study.
According to the study, all gargle samples were positive and comparable to their corresponding swab samples irrespective of the symptoms and duration of illness.
“The cycle threshold (C ) values for gargle samples were slightly higher but comparable to those of swabs. The majority (72%) of the patients reported moderate to severe discomfort with swab collection in comparison to 24 per cent reporting only mild discomfort with gargle collection,” it said adding that bland-altman plot showed good agreement between the two methods.
According to ICMR, swab collection has several drawbacks also as it requires training, exposes the healthcare workers (HCWs) to the virus-containing aerosols and has poor patient acceptability and is resource-intensive.
“An alternative sample collection method that could overcome most of these limitations without compromising the yield of the test is the need of the hour. One such method is the collection of gargle lavage. Although the use of gargle specimens is not new, at present, there is little published information on the suitability of gargle specimens to diagnose SARS- CoV-2 infection,” the study highlighted.
“Paired Nasopharyngeal and oropharyngeal swab (NPS and OPS) and gargle samples were taken within 72 hours of their diagnosis. Samples were processed by reverse transcription-polymerase chain reaction (RT-PCR) for detection of SARS-CoV-2. Post-sample collection, a 10-point scale was administered to assess the level of discomfort with either of the collection methods,” stated the study published in the Indian Journal of Medical Research (IJMR).
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